Soluble urokinase-type plasminogen activator receptor levels in patients with burn injuries and inhalation trauma requiring mechanical ventilation an observational cohort study 英文参考文献.docVIP

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Soluble urokinase-type plasminogen activator receptor levels in patients with burn injuries and inhalation trauma requiring mechanical ventilation an observational cohort study 英文参考文献.doc

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Soluble urokinase-type plasminogen activator receptor levels in patients with burn injuries and inhalation trauma requiring mechanical ventilation an observational cohort study 英文参考文献

Backesetal.CriticalCare2011,15:R270 /content/15/6/R270 RESEARCH OpenAccess Solubleurokinase-typeplasminogenactivator receptorlevelsinpatientswithburninjuriesand inhalationtraumarequiringmechanical ventilation:anobservationalcohortstudy YaraBackes1,2*,KoenraadFvanderSluijs2,AnitaMTuipdeBoer2,JorritJanHofstra2,3,AlexanderPJVlaar2,4, RogierMDetermann2,4,PaulKnape5,DavidPMackie5andMarcusJSchultz1,2 Abstract Introduction:Solubleurokinase-typeplasminogenactivatorreceptor(suPAR)hasbeenproposedasabiologic markeroffibrinolysisandinflammation.Theaimofthisstudywastoinvestigatethediagnosticandprognostic valueofsystemicandpulmonarylevelsofsuPARinburnpatientswithinhalationtraumawhoneedmechanical ventilation. Methods:suPARwasmeasuredinplasmaandnondirectedlung-lavagefluidofmechanicallyventilatedburn patientswithinhalationtrauma.Thesampleswereobtainedonthedayofinhalationtraumaandonalternatedays thereafteruntilpatientswerecompletelyweanedfromthemechanicalventilator.Mechanicallyventilatedpatients withoutburnsandwithoutpulmonarydiseaseservedascontrols. Results:SystemiclevelsofsuPARinburnpatientswithinhalationtraumawerenotdifferentfromthoseincontrol patients.Onadmissionandfollowup,pulmonarylevelsofsuPARinpatientswithinhalationtraumawere significantlyhighercomparedwithcontrols.PulmonarylevelsofsuPARhighlycorrelatedwithpulmonarylevelsof interleukin6,amarkerofinflammation,andthrombin-antithrombincomplexes,markersofcoagulation,butnot plasminogenactivatoractivity,amarkeroffibrinolysis.SystemiclevelsofsuPARwerepredictiveofthedurationof mechanicalventilationandlengthofintensivecareunit(ICU)stay.Durationofmechanicalventilationandlength ofICUstayweresignificantlylongerinburn-injurypatientswithsystemicsuPARlevels9.5ng/ml. Conclusions:PulmonarylevelsofsuPARareelevatedinburnpatientswithinhalationtrauma,andtheycorrelate withpulmonaryinflammationandcoagulation.AlthoughpulmonarylevelsofsuPARmayhavediagnosticvaluein burn-injurypatients,systemiclevelsofsuPARhaveprognosticvalue. Introduction andperiton