Solvent Free Fabrication of Micro and Nanostructured Drug Coatings by Thermal Evaporation for Controlled Release and Increased Effects 英文参考文献.docVIP

SolventFreeFabricationofMicroandNanostructured DrugCoatingsbyThermalEvaporationforControlled ReleaseandIncreasedEffects EmanS.Zarie1,ViktorKaidas1,DawitGedamu1,YogendraK.Mishra1,RainerAdelung1*, FranzH.Furkert2,ReginaScherlie?2,HartwigSteckel2,BirteGroessner-Schreiber3 1Functional Nanomaterials, Institute for Materials Science, Christian Albrechts University Kiel, Kaiserstrasse, Germany, 2Department of Pharmaceutics and Biopharmaceutics,ChristianAlbrechtsUniversityKiel,Grasweg,Kiel,Germany, 3DepartmentofOperativeDentistryandPeriodontology,ChristianAlbrechtsUniversity Kiel,Arnold-Heller-Kiel,Germany Abstract Nanostructuringofdrugdeliverysystemsoffersmanypromisingapplicationslikeprecisecontrolofdissolutionandrelease kinetics, enhanced activities, flexibility in terms of surface coatings, integration into implants, designing the appropriate scaffolds or even integrating into microelectronic chips etc. for different desired applications. In general such kind of structuring is difficultduetounintentional mixingofchemical solventsused during drugformulations.We demonstrate here the successful solvent-free fabrication of micro-nanostructured pharmaceutical molecules by simple thermal evaporation(TE).Theevaporationofdrugmoleculesandtheiremissiontoaspecificsurfaceundervacuumledtocontrolled assembling of the molecules from vapour phase to solid phase. The most important aspects of thermal evaporation techniqueare:solvent-free,precisecontrolofsize,possibilityoffabricatingmultilayer/hybrid,andfreechoiceofsubstrates. Thiscouldbeshownfortwentyeightpharmaceuticalsubstancesofdifferentchemicalstructureswhichwereevaporatedon surfaces of titaniumand glassdiscs. Structuralinvestigations of different TEfabricated drugs were performed by atomic force microscopy, scanning electron microscopy and Raman spectroscopy which revealed that these drug substances preservetheirstructuralityafterevaporation.Titaniumdiscscoatedwithantimicrobialsubstancesbythermalevaporation were subjected