Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α？Peptoids) and Derivatives 英文参考文献.docVIP

Molecules 2010, 15, 5282-5335; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α-Peptoids) and Derivatives Adrian S. Culf 1,2,* and Rodney J. Ouellette 1 1 Atlantic Cancer Research Institute, 35 Providence Street, Moncton, NB. EIC 8X3, Canada 2 Department of Chemistry and Biochemistry, Mount Allison University, 63C York Street, Sackville, NB. E4L 1G8, Canada * Author to whom correspondence should be addressed; E-Mails: adrianc@canceratl.ca; aculf@mta.ca; Tel.: +1 506 869 2020; Fax: +1 506 862 7571. Received: 4 June 2010; in revised form: 14 July 2010 / Accepted: 2 August 2010 / Published: 4 August 2010 Abstract: Peptoids (N-substituted polyglycines and extended peptoids with variant backbone amino-acid monomer units) are oligomeric synthetic polymers that are becoming a valuable molecular tool in the biosciences. Of particular interest are their applications to the exploration of peptoid secondary structures and drug design. Major advantages of peptoids as research and pharmaceutical tools include the ease and economy of synthesis, highly variable backbone and side-chain chemistry possibilities. At the same time, peptoids have been demonstrated as highly active in biological systems while resistant to proteolytic decay. This review with 227 references considers the solid-phase synthetic aspects of peptoid preparation and utilization up to 2010 from the instigation, by R. N. Zuckermann et al., of peptoid chemistry in 1992. Keywords: N-substituted polyglycine oligomer; peptoid; solid phase synthesis; synthetic methods 1. Introduction N-Substituted glycine oligomers (NSG), otherwise referred to as α-peptoids, are a readily accessible class of synthetic, non-natural peptide mimic of modular design into which a plethora of structural  Molecules 2010, 15 5283 elements can be readily incorpor