Solitary pancreatic lymph node metastasis from carcinoma of the breast case report 英文参考文献.docVIP

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Solitary pancreatic lymph node metastasis from carcinoma of the breast case report 英文参考文献.doc

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Solitary pancreatic lymph node metastasis from carcinoma of the breast case report 英文参考文献

Corradoetal.DiagnosticPathology2010,5:29 /content/5/1/29 CASE REPORT OpenAccess Solitarypancreaticlymphnodemetastasisfrom carcinomaofthebreast:casereport GiacomoCorrado1*,GiorgiaGarganese1,GildaFuoco1,ArnaldoCarbone2,GiovanniScambia1,GabriellaFerrandina1 Abstract Background:Wereportthefirstcaseofisolatedpancreaticlymphnoderecurrenceinalocallyadvancedbreast cancerpatient. Case:A41-yearoldwomanunderwentradicalmastectomyaccordingtoMaddenandremovalofaxillarylymph nodesformulticentricinfiltratingductalcarcinomapathologicallystagedaspT2N2M0.Aftersixyearsfromprimary diagnosis,andfouryearsfromthediagnosisoflungrecurrence,shedevelopedanisolatedmetastaticlesionto pancreaticlymphnode.Aftersurgicalexcisionofmetastasis,hormonetherapywithExemestanewasbegun.At16 monthsoffollow-up,thepatientappearsfreeofdisease. Conclusion:Becausemetastatizationtovisceralorgancarriesaveryunfavorableprognosis,wethinkthatthe clinicalsignificanceoftheelevationofCA15.3serumlevelsintheearlydetectionofrecurrenceandinmonitoring metastaticdiseaseduringfollow-up,shouldbenotunderestimated. Background and underwent radical mastectomy according to Mad- Breastcancerisoneofthemostcommoncausesofcan- denandremovalof18axillarylymphnodesforamulti- cer-relateddeathinwomen[1].Haematogenousmetas- centric infiltrating moderately differentiated ductal tases to lung, bone, liver and brain represent the most carcinoma (2 cm maximum diameter); lymphovascular frequent sites of disease recurrence [2], and once they space invasion was positive, and 8 lymph nodes were occurpatients’clinicaloutcomeisdismal. showntocontainmalignantcells. Metastatic involvement of pancreas and its lymph The tumor was positive for both estrogen receptors nodesfromanothersiteisuncommonandaccountsfor (ER)(90%)andprogesteronereceptors(PR)(70%),nega- approximately 2% of pancreatic malignancies [3]. In tive for human epidermal growth factor receptor 2 largeautopsyseriestheprevalenceofpancreaticmetas- (c-erbB-2),andpositivef