Soluble Interleukin-6 Receptor Induces Motor Stereotypies and Co-Localizes with Gp130 in Regions Linked to Cortico-Striato-Thalamo-Cortical Circuits 英文参考文献.docVIP

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Soluble Interleukin-6 Receptor Induces Motor Stereotypies and Co-Localizes with Gp130 in Regions Linked to Cortico-Striato-Thalamo-Cortical Circuits 英文参考文献.doc

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Soluble Interleukin-6 Receptor Induces Motor Stereotypies and Co-Localizes with Gp130 in Regions Linked to Cortico-Striato-Thalamo-Cortical Circuits 英文参考文献

SolubleInterleukin-6ReceptorInducesMotor StereotypiesandCo-LocalizeswithGp130inRegions LinkedtoCortico-Striato-Thalamo-CorticalCircuits AnkurPatel1*,YouhuaZhu2,EldoV.Kuzhikandathil3,WilliamA.Banks4,AllanSiegel5, StevenS.Zalcman2 1DepartmentofNeurologyandNeurosciences,NewJerseyMedicalSchool,UniversityofMedicineandDentistryofNewJersey,Newark,NewJersey,UnitedStatesof America, 2Department ofPsychiatry,New Jersey MedicalSchool, University of Medicine and Dentistry of New Jersey,Newark, NewJersey, United States of America, 3DepartmentofPharmacologyandPhysiology,NewJerseyMedicalSchool,UniversityofMedicineandDentistryofNewJersey,Newark,NewJersey,UnitedStatesof America, 4Division of Gerontology and Geriatric Medicine, Department of Medicine, Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound HealthCareSystem,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica,5DepartmentofNeurologyandNeurosciences,NewJerseyMedicalSchool, UniversityofMedicineandDentistryofNewJersey,Newark,NewJersey,UnitedStatesofAmerica Abstract Solublecytokinereceptorsarenormalconstituentsofbodyfluidsthatregulateperipheralcytokineandlymphoidactivity and whose levels are increased in states of immune activation. Soluble interleukin-6 receptor (sIL-6R) levels positively correlate with disease progression in some autoimmune conditions and psychiatric disorders. Particularly strong links betweenlevelsofsIL-6Randtheseverityofpsychoticsymptomsoccurinschizophrenia,raisingthepossibilitythatsIL-6Ris involvedinthisdisease.However,thereisnoevidencethatperipheralsIL-6Rinducesrelevantbehavioraldisturbances.We showed that single subcutaneous injections of sIL-6R (0–1mg), stimulated novelty stress-induced exploratory motor behaviorsinmaleBalb/cmicewithin20–40-minofinjection.Aprogressiveincreaseinverticalstereotypieswasobserved 40–80minpostinjection,persistingfortheremainderofthetestsession.Parallelingthesestimulant-likeeffects,sIL-6Rpre- treatment significantly enhanced stereotypy