Soil-Transmitted Helminth Reinfection after Drug Treatment A Systematic Review and Meta-Analysis 英文参考文献.docVIP

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Soil-Transmitted Helminth Reinfection after Drug Treatment A Systematic Review and Meta-Analysis 英文参考文献.doc

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Soil-Transmitted Helminth Reinfection after Drug Treatment A Systematic Review and Meta-Analysis 英文参考文献

Soil-TransmittedHelminthReinfectionafterDrug Treatment:ASystematicReviewandMeta-Analysis Tie-WuJia1*,SaraMelville2,Ju¨rgUtzinger3,4,CharlesH.King5,Xiao-NongZhou1* 1KeyLaboratoryonBiologyofParasitesandVectors,MOH,WHOCollaboratingCenteronMalaria,SchistosomiasisandFilariasis,NationalInstituteofParasiticDiseases, ChineseCenter for Disease ControlandPrevention, Shanghai,People’sRepublicofChina, 2HughesHallCollege,CambridgeUniversity, Cambridge,United Kingdom, 3Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, 4University of Basel, Basel, Switzerland, 5Center for GlobalHealthandDiseases,CaseWesternReserveUniversitySchoolofMedicine,Cleveland,Ohio,UnitedStatesofAmerica Abstract Background:Soil-transmittedhelminth(STH)infections(i.e.,Ascarislumbricoides,hookworm,andTrichuristrichiura )affect more than a billion people. Preventive chemotherapy (i.e., repeated administration of anthelmintic drugs to at-risk populations),isthemainstayofcontrol.Thisstrategy,however,doesnotpreventreinfection.Weperformedasystematic reviewandmeta-analysistoassesspatternsanddynamicsofSTHreinfectionafterdrugtreatment. Methodology:WesystematicallysearchedPubMed,ISIWebofScience,EMBASE,CochraneDatabaseofSystematicReviews, China National Knowledge Infrastructure, WanFang Database, Chinese Scientific Journal Database, and Google Scholar. Information on study year, country, sample size, age of participants, diagnostic method, drug administration strategy, prevalenceandintensityofinfectionpre-andposttreatment,cureandeggreductionrate,evaluationperiodposttreatment, andadherencewasextracted.Pooledriskratiosfromrandom-effectsmodelswereusedtoassesstheriskofSTHreinfection aftertreatment.OurprotocolisavailableonPROSPERO,registrationnumber:CRD42011001678. Principal Findings: From 154 studies identified, 51 were included and 24 provided STH infection rates pre- and posttreatment,whereas42reporteddeterminantsofpredispositiontoreinfection.At3,6,and12mo