Soft X-ray Laser Microscopy of Lipid Rafts towards GPCR-Based Drug Discovery Using Time-Resolved FRET Spectroscopy 英文参考文献.docVIP

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Soft X-ray Laser Microscopy of Lipid Rafts towards GPCR-Based Drug Discovery Using Time-Resolved FRET Spectroscopy 英文参考文献.doc

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Soft X-ray Laser Microscopy of Lipid Rafts towards GPCR-Based Drug Discovery Using Time-Resolved FRET Spectroscopy 英文参考文献

Pharmaceuticals 2011, 4, 524-550; doi:10.3390/ph4030524 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review Soft X-ray Laser Microscopy of Lipid Rafts towards GPCR- Based Drug Discovery Using Time-Resolved FRET Spectroscopy Motoyoshi Baba 1,2,*, Tohru Kozasa 3,4, Takao Hamakubo 3, Hiroto Kuroda 2, Kazuyuki Masuda 3, Shin Yoneya 2 and Tatsuhiko Kodama 3 1 Institute for Solid State Physics, University of Tokyo, Chiba 277, Japan 2 Department of Ophthalmology and Advanced Laser Medical Center, Faculty of Medicine, Saitama Medical University, Saitama 350, Japan; E-Mails: kuroda@saitama-med.ac.jp (H.K.); shin@saitama-med.ac.jp (S.Y.) 3 Laboratory for System Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153, Japan; E-Mails: kodama@ (T.K.); hamakubo@ (T.H.); masuda@ (K.M.) 4 Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA; E-Mail: tkozas@ (T.K.) * Author to whom correspondence should be addressed; E-Mail: baba@issp.u-tokyo.ac.jp or mbaba@saitama-med.ac.jp; Tel.: +81-4-7136-3367; Fax: +81-4-7136-3377 or Tel. / Fax +81-49-276-1224. Received: 17 December 2010; in revised form: 7 March 2011 / Accepted: 7 March 2011 / Published: 14 March 2011 Abstract: Many signaling molecules involved in G protein-mediated signal transduction, which are present in the lipid rafts and believed to be controlled spatially and temporally, influence the potency and efficacy of neurotransmitter receptors and transporters. This has focus interest on lipid rafts and the notion that these microdomains acts as a kind of signaling platform and thus have an important role in the expression of membrane receptor-mediated signal transduction, cancer, immune responses, neurotransmission, viral infections and various other phenomena due to specific and efficient signaling according to extracellular stimuli. However, the real structur