Softlithography in Chemical Sensing – Analytes from Molecules to Cells 英文参考文献.docVIP

Sensors 2005, 5, 509-518 sensors ISSN 1424-8220 ? 2005 by MDPI /sensors Softlithography in Chemical Sensing – Analytes from Molecules to Cells Peter A. Lieberzeit 1, Gerd Glanznig 1, Michael Jenik 1, Sylwia Gazda-Miarecka 1, Franz L. Dickert 1,* and Anton Leidl 2 1 Institute for Analytical Chemistry and Food Chemistry, Faculty of Chemistry, Vienna University, Waehringer Strasse 38, A-1090 Vienna, Austria Tel.: +43/1/4277-52317, Fax.: +43/1/4277-9523, e-mail: Franz.Dickert@univie.ac.at 2 EPCOS AG, SAW RD IP, Anzingerstrasse 13, D-81617 München, Germany Received: 5 September 2005 / Accepted: 28 November 2005 / Published: 1 December 2005 Abstract: Imprinting is a flexible and straightforward technique to generate selective sensor materials e.g. for mass-sensitive detection. Inherently, the strategy suits both molecular analytes and entire micro organisms or cells. Imprinted polyurethanes e.g. are capable of distinguishing the different xylene isomers with very appreciable selectivity factors. Combining imprinted titanates with surface transverse wave resonators (STW) leads to a powerful tool for detecting engine oil degradation, which is an excellent example for oxidative deterioration processes in a highly complex matrix. Surface imprints with geometrically equal cavities exhibit clear chemical selectivity, as can e.g. be seen through the example of different human rhinovirus (HRV) serotypes. Another example is a blood group-selective sensor prepared by templating with erythrocyte ghosts. Both the blood- group A and B imprinted material selectively distinguish between blood groups A, B and O, whereas no difference in sensor signal has been observed for AB, where both blood group antigen types are present on the cell surface. Keywords: Imprinting, QCM, SAW, VOCs detection, engine oil degradation, HRV, erythrocytes.  Sensors 2005, 5 510 1. Introduction