Standardisation of data collection in traumatic brain injury key to the future 英文参考文献.docVIP

Available online /content/13/6/1016 Commentary Standardisation of data collection in traumatic brain injury: key to the future? Andrew IR Maas Department of Neurosurgery, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium Corresponding author: Andrew IR Maas, andrew.maas@uza.be Published: 16 December 2009 Critical Care 2009, 13:1016 (doi:10.1186/cc8163) This article is online at /content/13/6/1016 ? 2009 BioMed Central Ltd Abstract comparisons between studies, and complicating meta- analyses of individual patient data. Great variability exists in data collection and coding of variables in studies on traumatic brain injury (TBI). This confounds comparison of results and analysis of data across studies. The difficulties in performing a meta-analysis of individual patient data were recently Analysing individual patient data across studies may well be key to advancing the clinical field of TBI, and improving treat- ment. Much uncertainty exists regarding the benefit and risk of many treatment modalities in TBI. This uncertainty is reflected in the paucity of class I and II evidence underpinning authoritative guideline recommendations [3]. Although rando- mized controlled trials remain the prime approach for investiga- illustrated in the IMPACT project (International Mission on Prognosis and Clinical Trial Design in TBI): merging data from 11 studies involved over 10 person years of work. However, these studies did confirm the great potential for advancing the field by this approach. Although randomized controlled trials remain the prime approach for investigating treatment effects, these can never address the many uncertainties concerning multiple treatment modalities in TBI. Pooling data from different studies may provide the best possible source of evidence we can get in a cost efficient way. Standardisation of data collection and coding is es