Structure of Salvioccidentalin, a Diterpenoid with a Rearranged neo-Clerodane Skeleton from Salvia occidentalis 英文参考文献.docVIP

Molecules 2011, 16, 9109-9115; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication Structure of Salvioccidentalin, a Diterpenoid with a Rearranged neo-Clerodane Skeleton from Salvia occidentalis Miguel ángel Jaime-Vasconcelos, Bernardo Antonio Frontana-Uribe, José Antonio Morales-Serna, Manuel Salmón and Jorge Cárdenas * Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510 México D. F., México; E-Mails: mguelajv@ (M.A.J.-V.); bafrontu@unam.mx (B.A.F.-U.); morser@unam.mx (J.A.M.-S.); salmon@unam.mx (M.S.) * Author to whom correspondence should be addressed; E-Mail: rjcp@unam.mx; Tel.: +52-55-5622-4413; Fax: +52-55-5616-2217. Received: 14 September 2011; in revised form: 21 October 2011 / Accepted: 26 October 2011 / Published: 31 October 2011 Abstract: From the aerial parts of Salvia occidentalis (Labiatae) a new diterpenoid with a rearranged neo-clerodane skeleton was isolated. This new compound was named salvioccidentalin and its structure was established by spectroscopic means. A probable biogenetic relationship with salvigenolide from S. fulgens and salvileucalin A and spiroleucantholide from Salvia leucantha is proposed. Keywords: Salvia occidentalis; Labiatae; diterpene; neo-clerodane; NMR 1. Introduction The Labiatae family comprises about 220 genera and 4,000 species. Some species of this family have economic importance due to their essential oil content [1] or their use in folk medicine, which is frequently related to the diterpenoid content of the plants [2-4]. One of the largest genus of the family, Salvia L., is represented by over 900 species, and is widely distributed in various regions of the world [5]. In Mexico, the Labiatae family is well represented, mainly by the genus Salvia, subgenus Calosphace, which is one of the largest in our country with over 257 species