Structure-Composition-Property Relationships in Polymeric Amorphous Calcium Phosphate-Based Dental Composites 英文参考文献.docVIP

Materials 2009, 2, 1929-1954; doi:10.3390/ma2041929 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Article Structure-Composition-Property Relationships in Polymeric Amorphous Calcium Phosphate-Based Dental Composites ? Justin N.R. O’Donnell 1, Gary E. Schumacher 1, Joseph M. Antonucci 2 and Drago Skrtic 1,* 1 Paffenbarger Research Center, American Dental Association Foundation, Gaithersburg, 20899, MD, USA; E-Mails: justin.odonell@ (J.N.R.O’D.); gary.schumacher@ (G.E.S.) 2 Polymers Division, National Institute of Standards and Technology, Gaithersburg, 20899, MD, USA; E-Mail: joe.antonucci@ (J.M.A.) ? Official contribution of NIST; not subject to copyrights in USA. * Author to whom correspondence should be addressed; E-Mail: drago.skrtic@; Tel.: 301-975-3541; Fax: 301-963-9143. Received: 30 October 2009; in revised form: 19 November 2009 / Accepted: 23 November 2009 / Published: 24 November 2009 Abstract: Our studies of amorphous calcium phosphate (ACP)-based materials over the last decade have yielded bioactive polymeric composites capable of protecting teeth from demineralization or even regenerating lost tooth mineral. The anti-cariogenic/re- mineralizing potential of these ACP composites originates from their propensity, when exposed to the oral environment, to release in a sustained manner sufficient levels of mineral-forming calcium and phosphate ions to promote formation of stable apatitic tooth mineral. However, the less than optimal ACP filler/resin matrix cohesion, excessive polymerization shrinkage and water sorption of these experimental materials can adversely affect their physicochemical and mechanical properties, and, ultimately, limit their lifespan. This study demonstrates the effects of chemical structure and composition of the methacrylate monomers used to form the matrix phase of composites on degree of vinyl conversion (DVC) and water sorptio