Study of the in Vitro Antiplasmodial, Antileishmanial and Antitrypanosomal Activities of Medicinal Plants from Saudi Arabia 英文参考文献.docVIP

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Study of the in Vitro Antiplasmodial, Antileishmanial and Antitrypanosomal Activities of Medicinal Plants from Saudi Arabia 英文参考文献.doc

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Study of the in Vitro Antiplasmodial, Antileishmanial and Antitrypanosomal Activities of Medicinal Plants from Saudi Arabia 英文参考文献

Molecules 2012, 17, 11379-11390; doi:10.3390/molecules171011379 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Study of the in Vitro Antiplasmodial, Antileishmanial and Antitrypanosomal Activities of Medicinal Plants from Saudi Arabia Nawal M. Al-Musayeib 1, Ramzi A. Mothana 1,2,*, Shaza Al-Massarani 1, An Matheeussen 3, Paul Cos 3 and Louis Maes 3 1 Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; E-Mails: nalmusayeib@.sa (N.M.A.-M.); salmassarani@.sa (S.A.-M.) 2 Department of Pharmacognosy, Faculty of Pharmacy, Sana’a University, P.O. Box 33039, Sana’a, Yemen 3 Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium; E-Mails: an.matheeussen@ua.ac.be (P.C.); paul.cos@ua.ac.be; louis.maes@ua.ac.be (L.M.) * Author to whom correspondence should be addressed; E-Mails: rmothana@.sa; r_mothana@; Tel.: +966-1-467-7256; Fax: +966-1-467-7245. Received: 8 August 2012; in revised form: 15 September 2012 / Accepted: 18 September 2012 / Published: 25 September 2012 Abstract: The present study investigated the in vitro antiprotozoal activity of sixteen selected medicinal plants. Plant materials were extracted with methanol and screened in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxic activity was determined against MRC-5 cells to assess selectivity. The criterion for activity was an IC50 10 μg/mL (5 μg/mL for T. brucei) and a selectivity index of 4. Antiplasmodial activity was found in the extracts of Prosopis juliflora and Punica granatum. Antileishmanial activity against L. infantum was demonstrated in Caralluma sinaica and Periploca aphylla. Amastigot