Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa Frequency and clinical significance 英文参考文献.docVIP

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Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa Frequency and clinical significance 英文参考文献.doc

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Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa Frequency and clinical significance 英文参考文献

AIDS Research and Therapy BioMedCentral Research Open Access Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance Damalie Nakanjako*1, Agnes Kiragga1, Fowzia Ibrahim2, Barbara Castelnuovo1, Moses R Kamya1 and Philippa J Easterbrook1,2 Address: 1Infectious Diseases Institute, Facluty of Medicine, Makerere University Kampala, Uganda and 2Department of HIV/GUM, Kings College London, SWZ, London, UK Email: Damalie Nakanjako* - drdamalie@; Agnes Kiragga - akiragga@idi.co.ug; Fowzia Ibrahim - fowzia.ibrahim@kcl.ac.uk; Barbara Castelnuovo - bcastelnuovo@idi.co.ug; Moses R Kamya - mkamya@infocom.co.ug; Philippa J Easterbrook - peasterbrook@idi.co.ug * Corresponding author Published: 28 October 2008 Received: 22 July 2008 Accepted: 28 October 2008 AIDS Research and Therapy 2008, 5:23 doi:10.1186/1742-6405-5-23 This article is available from: /content/5/1/23 ? 2008 Nakanjako et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: A proportion of individuals who start antiretroviral therapy (ART) fail to achieve adequate CD4 cell reconstitution despite sustained viral suppression. We determined the frequency and clinical significance of suboptimal CD4 reconstitution despite viral suppression (SO- CD4) in an urban HIV research cohort in Kampala, Uganda Methods: We analyzed data from a prospective research cohort of 559 patients initiating ART between 04/04–04/05. We described the patterns of SO-CD4 both in terms of:- I) magnitude of CD4 cell increase (a CD4 count increase 50 CD4 cells/μl at 6 months, 100 cells/μl at 12 months; and 200 cells/μl at 24 months of ART) and II