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Targeted therapies in colorectal cancer---an integrative view by PPPM 英文参考文献
Haganetal.TheEPMAJournal2013,4:3
/content/4/1/3
REVIEW
OpenAccess
Targetedtherapiesincolorectalcancer—an
integrativeviewbyPPPM
SuzanneHagan1*,MariaCMOrr2andBrendanDoyle3
Abstract
Indevelopedcountries,colorectalcancer(CRC)isthethirdmostcommonmalignancy,butitisthesecondmost
frequentcauseofcancer-relateddeath.Cliniciansarestillfacedwithnumerouschallengesinthetreatmentofthis
disease,andfutureapproacheswhichtargetthemolecularfeaturesofthedisorderwillbecriticalforsuccessinthis
diseasesetting.Geneticanalysesofmanysolidtumourshaveshownthatupto100protein-encodinggenesare
mutated.WithinCRC,numerousgen
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