Targeting DNA with Anthracyclines The Importance of the Sugar Moiety 英文参考文献.docVIP

299 Molecules 2000, 5 Targeting DNA with Anthracyclines: The Importance of the Sugar Moiety Waldemar Priebe The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030 Our studies focusing on the role of the sugar portion in anthracycline-DNA interaction laid the foundation for the design of novel DNA interactive agents. We have designed and synthesized two new classes of such agents which: (1) bind with high affinity to specific sequences of DNA and (2) form cross-links with DNA. The design of agents binding with high affinity to specific sequences o