The ADAMs family of proteases new biomarkers and therapeutic targets for cancer 英文参考文献.docVIP

Duffyetal.ClinicalProteomics2011,8:9 /content/8/1/9 CLINICAL PROTEOMICS REVIEW OpenAccess TheADAMsfamilyofproteases:newbiomarkers andtherapeutictargetsforcancer? MichaelJDuffy1,2*,MaeveMullooly1,2,NormaO’Donovan3,SumainizahSukor2,4,JohnCrown4,AislingPierce1,2and PatriciaMMcGowan1,2 *Correspondence:michael.j. Abstract duffy@ucd.ie 1DepartmentofPathologyand TheADAMsaretransmembraneproteinsimplicatedinproteolysisandcelladhesion. Fortygenemembersofthefamilyhavebeenidentified,ofwhich21arebelievedto befunctionalinhumans.Asproteases,theirmainsubstratesaretheectodomainsof othertransmembraneproteins.