The analysis of disease biomarker data using a mixed hidden Markov model (Open Access publication) 英文参考文献.docVIP

Genet.Sel.Evol.40(2008)491–509 óINRA,EDPSciences,2008 DOI: Availableonlineat: Originalarticle Theanalysisofdiseasebiomarkerdatausing amixedhiddenMarkovmodel (OpenAccesspublication) JohannC.DETILLEUX* QuantitativeGeneticsGroup,DepartmentofAnimalProduction, FacultyofVeterinaryMedicine,UniversityofLie`ge, Lie`ge, Belgium (Received13September2007;accepted3rdMarch2008) Abstract–A mixed hidden Markov model (HMM) was developed for predicting breedingvaluesofabiomarker(here,somaticcellscore)andtheindividualprobabilities ofhealthanddisease(here,mastitis)baseduponthemeasurementsofthebiomarker.At