The culprit behind amyloid beta peptide related neurotoxicity in Alzheimers disease oligomer size or conformation 英文参考文献.docVIP

Broersen et al. Alzheimer’s Research Therapy 2010,2:12 /content/2/4/12 RE VIE W The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer’s disease: oligomer size or conformation? Kerensa Broersen, Frederic Rousseau and Joost Schymkowitz* Aβ containing plaques in the brain and the severity of the Abstract neurodegenerative symptoms observed in AD patients Since the reformulation of the amyloid cascade hypothesis to focus on oligomeric aggregates of amyloid beta as the prime toxic species causing Alzheimer’s disease, many researchers refocused on erefore, the foc