原创力文档The CXCR4-CXCL12 axis in Ewing sarcoma promotion of tumor growth rather than metastatic disease 英文参考文献.docVIP
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The CXCR4-CXCL12 axis in Ewing sarcoma promotion of tumor growth rather than metastatic disease 英文参考文献
Berghuisetal.ClinicalSarcomaResearch2012,2:24
/content/2/1/24
CLINICAL SARCOMA RESEARCH
RESEARCH
OpenAccess
TheCXCR4-CXCL12axisinEwingsarcoma:
promotionoftumorgrowthratherthan
metastaticdisease
DagmarBerghuis1,2,MarcoWSchilham2,SusyJSantos2,SuviSavola3,HelenJKnowles4,UtaDirksen5,
Karl-LudwigSchaefer6,JukkaVakkila3,PancrasCWHogendoorn1andArjanCLankester2*
Abstract
Background:ChemokinereceptorCXCR4,togetherwithitsligandCXCL12,playscriticalrolesincancerprogression,
includinggrowth,metastasisandangiogenesis.Ewingsarcomaisasarcomawithpoorprognosisdespitecurrent
therapies,particularlyforpatientswi
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