The effects of linkage disequilibrium in large scale SNP datasets for MDR 英文参考文献.docVIP

Gradyetal.BioDataMining2011,4:11 /content/4/1/11 BioData Mining RESEARCH OpenAccess Theeffectsoflinkagedisequilibriuminlarge scaleSNPdatasetsforMDR BenjaminJGrady,EricSTorstensonandMarylynDRitchie* *Correspondence:ritchie@chgr.mc. Abstract CenterforHumanGenetics Research,VanderbiltUniversity MedicalCenter,Nashville,TN Background:Intheanalysisoflarge-scalegenomicdatasets,animportant considerationisthepowerofanalyticalmethodstoidentifyaccuratepredictive 37232,USA modelsofdisease.Whentryingtoassesssensitivityfromsuchanalyticalmethods,a confoundingfactoruptothispointhasbeenthepresenceoflinkagedi