The involvement of cell cycle events in the pathogenesis of Alzheimers disease 英文参考文献.docVIP

Herrup Alzheimer’s Research Therapy 2010,2:13 /content/2/3/13 COMMENTARY The involvement of cell cycle events in the pathogenesis of Alzheimer’s disease Karl Herrup* neuro toxins (including Aβ aggregates), it will re-enter a Abstract cy e cell cycle events are directly involved Most neurons undergo their last cell division within the ?rst 1 to 2% of the lifespan of an organism. This has been interpreted to mean that adult neurons are permanently postmitotic, but Alzheimer’s disease (AD) is an example of a late-onset neurodegenerative disease that challenges this concept. In AD, neurons i