The mouse genetics toolkit revealing function and mechanism 英文参考文献.docVIP

van der Weyden et al. Genome Biology 2011,12:224 /2011/12/6/224 RE VIE W The mouse genetics toolkit: revealing function and mechanism Louise van der Weyden, Jacqueline K White, David J Adams* and Darren W Logan strain genomes has started, and e?orts are under way to Abstract systematically disrupt every gene in the mouse genome Large-scale projects are providing rapid global access to a wealth of mouse genetic resources to help discover disease genes and to manipulate their function. and phenotype the resulting mutant animals [4]. Here, we outline the tools and technologies that