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The p-i concept Pharmacological interaction of drugs with immune receptors 英文参考文献
REVIEWARTICLE
Thep-iConcept:PharmacologicalInteractionofDrugs
WithImmuneReceptors
WernerJ.Pichler
I
n drug hypersensitivity, 2 extremely polymorphic systems
encountereachother.Ononehand,modernchemistry,which
Abstract:Theimmuneresponseindrughypersensitivityisnormally
explained by the hapten hypothesis. It postulates that drugs with a
molecularweightoflessthan1000Daretoosmalltocauseanimmune
response per se. However, if a chemically reactive drug or drug
metabolitebindscovalentlytoaproteinandthusformsaso-called
hapten-carriercomplex,thismodi?edproteincaninduceanimmune
response. This concept has
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