The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol 英文参考文献.docVIP

Tanner et al. BMC Clinical Pharmacology 2010, 10:10 /1472-6904/10/10 RESEARCH ARTICLE Open Access The pharmacokinetic profile of a novel fixed-dose Research article combination tablet of ibuprofen and paracetamol Trevor Tanner*1, Sue Aspley2, Andrew Munn1 and Tracy Thomas1 Abstract Background: Ibuprofen and paracetamol differ in their mode of action and related therapeutic effects, suggesting that combined administration may offer improved analgesia. Reported here are the results of two studies on the pharmacokinetic properties of a novel ibuprofen (200 mg) and paracetamol (500 mg) fix