The use of prophylactic fluconazole in immunocompetent high-risk surgical patients a meta-analysis 英文参考文献.docVIP

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The use of prophylactic fluconazole in immunocompetent high-risk surgical patients a meta-analysis 英文参考文献.doc

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The use of prophylactic fluconazole in immunocompetent high-risk surgical patients a meta-analysis 英文参考文献

Available online /content/9/6/R710 Research Open Access Vol 9 No 6 The use of prophylactic fluconazole in immunocompetent high-risk surgical patients: a meta-analysis Kwok M Ho1, Jeffrey Lipman2, Geoffrey J Dobb3 and Steven AR Webb4 1Consultant Intensivist, Department of Intensive Care, Royal Perth Hospital, Australia 2Professor and Head of the Department, Department of Intensive Care Medicine, Royal Brisbane Hospital, University of Queensland, Australia 3Acting Head of the Department, Department of Intensive Care, Royal Perth Hospital, Australia and Associate Professor, School of Medicine and Pharmacology, University of Western Australia, Australia 4Consultant Intensivist, Department of Intensive Care, Royal Perth Hospital, Australia and Senior Lecturer, School of Medicine and Pharmacology, University of Western Australia, Australia Corresponding author: Kwok M Ho, kwok.ho@.au Received: 23 Aug 2005 Accepted: 28 Sep 2005 Published: 25 Oct 2005 Critical Care 2005, 9:R710-R717 (DOI 10.1186/cc3883) This article is online at: /content/9/6/R710 ? 2005 Ho et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction High-risk surgical patients are at increased risk of fungal infections and candidaemia. Evidence from observational with a reduction in the proportion of patients with candidaemia (relative risk [RR] = 0.21, 95% confidence interval [CI] = 0.06– and small randomised controlled studies suggests that 0.72, P = 0.01; I2 = 0%) and fungal infections other than lower urinary tract infection (RR = 0.39, 95% CI = 0.24–0.65, P = 0.0003; I2 = 0%), but was associated with only a trend towards a reduction in hospital mortality (RR = 0.82, 95% CI = 0.62– 1.08, P = 0.15; I2 = 7%). The proportion of patients requir