Three New Caffeoyl Glycosides from the Roots of Picrorhiza Scrophulariiflora 英文参考文献.docVIP

Molecules 2008, 13, 729-735 molecules ISSN 1420-3049 ? 2008 by MDPI /molecules Full Paper Three New Caffeoyl Glycosides from the Roots of Picrorhiza Scrophulariiflora Tong Fei Zhu 1, 2, Kai Yi Huang 2, Xu Ming Deng 1,*, Yu Zhang 2, Hua Xiang 1, Hui Yuan Gao 2 and Da Cheng Wang 1,* 1 College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, P. R. China 2 School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China; E-mail: imi224@ (Zhu) *Author to whom correspondence should be addressed; E-mail: xumingdeng@; wdc9928@; Fax: (+86)-431Received: 2 February 2008 / Accepted: 24 March 2008 / Published: 27 March 2008 Abstract: From the underground parts of Picrorhiza scrophulariiflora, three new caffeoyl glycosides, scrocaffeside A-C (1-3), together with two caffeic acid derivates, 4-O-β-D- glucopyranosyl caffeic acid (4) and 4-methoxycaffeic acid (5) and a phenylethanoid glycoside, scroside D (6), were isolated. Their structures were elucidated on the basis of chemical and spectroscopic evidence and comparisons with literature data of related compounds. Keywords: Picrorhiza scrophulariiflora, caffeoyl glycosides, scrocaffeside A-C. Introduction The plant Picrorhiza scrophulariiflora (Scrophulariaceae) grows in the high altitude regions (over 4400 m) in the southeast of Tibet and the northwest of Yunnan in China. The roots of this plant are used in traditional Chinese medicine for the treatment of damp-heat dysentery, jaundice and steaming bone disorder [1]. Previous phytochemical investigations of this plant led to the isolation of terpenoids [2, 3, 4], iridoid glycosides [5, 6, 7], phenolic glycosides and phenylethanoid glycosides [8-14]. Here we report the isolation and characterization of three new caffeoyl glycosides 1-3, as well as three  Molecules 2008, 13 730 known compounds. Results and Discussion The three