Three New Phytoecdysteroids Containing a Furan Ring from the Roots of Achyranthes bidentata Bl. 英文参考文献.docVIP

Molecules 2011, 16, 5989-5997; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Three New Phytoecdysteroids Containing a Furan Ring from the Roots of Achyranthes bidentata Bl. Qiu-Hong Wang ?, Liu Yang ?, Hai Jiang, Zhi-Bin Wang, Bing-You Yang and Hai-Xue Kuang * Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine), Ministry of Education, No. 24 HePing Road, XiangFang District, Harbin 150040, China ? These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: hxkuang@; Tel.: +86-451 Fax: +86-451 Received: 10 May 2011; in revised form: 13 July 2011 / Accepted: 13 July 2011 / Published: 18 July 2011 Abstract: Three new phytoecdysteroid compounds, named niuxixinsterone A (1), B (2) and C (3) with acetal functions in the side-chain were isolated from Achyranthes bidentata Bl. The structures were established as (20R,22R,24S)-20-O,22-O-(5′-hydroxymethyl)- furfurylidene-2β,3β,14α,25-tetrahydroxy-5β-ergost-7-en-6-one (1), (20R,22R)-20-O,22-O- (5′-hydroxymethyl)-furfurylidene-2β,3β,25-trihydroxy-14β-methyl-18-nor-5β-cholesta-7,12- dien-6-one (2) and (20R,22R,25R)-20-O,22-O-(5′-hydroxymethyl)-furfurylidene-2β, 3β,5β,14α,26-pentahydroxycholest-7-en-6-one (3) by means of spectroscopic evidence. Keywords: Achyranthes bidentata Bl.; phytoecdysteroid; niuxixinsterone 1. Introduction Achyranthes bidentata Bl., a member of Amaranthaceae, is an erect perennial herbaceous plant widely distributed and grown in hilly districts of India, China, Japan and Java. The roots of A. bidentata named “Niuxi” in Chinese, is an important medicinal herbal and documented in the Chinese Pharmacopeia. It is usually prescribed by practitioners of Traditional Chinese Medicine (TCM) as a tonic, emmenagogue, antiarthritic, diuretic, and antifertility agent to nourish the liver and kidneys, str