Tissue hemoglobin index a non-invasive optical measure of total tissue hemoglobin 英文参考文献.docVIP

Available online /content/13/S5/S2 Research Tissue hemoglobin index: a non-invasive optical measure of total tissue hemoglobin Dean Myers1, Michelle McGraw1, Mark George2, Kristine Mulier2 and Greg Beilman2 1BioMeasurement Division, Hutchinson Technology Inc., 40 West Highland Park Drive NE, Hutchinson, MN 55350-9784, USA 2Department of Surgery, University of Minnesota, MMC 11, 420 Delaware St SE, Minneapolis, Minnesota 55455-0390, USA Corresponding author: Dean Myers, dean.myers@ Published: 30 November 2009 Critical Care 2009, 13(Suppl 5):S2 (doi:10.1186/cc8000) This article is online at /content/13/S5/S2 ? 2009 BioMed Central Ltd Abstract Introduction The InSpectra? StO2 Tissue Oxygenation Monitor, Model 650 (Hutchinson Technology Inc., Hutchinson, MN, USA) provides continuous non-invasive assessment of tissue hemo- globin oxygen saturation (StO2) in the clinical setting. Depressed StO2 has been shown to correlate with the severity of systemic hypoperfusion and mortality in traumatic shock patients [1,2] and septic shock patients [3,4]. In addition to StO2, the InSpectra? monitor displays the tissue hemoglobin index (THI), a measurement of hemoglobin signal strength useful for determining whether the StO2 sensor is optimally positioned over muscle. Introduction: The tissue hemoglobin index (THI) is a hemoglobin signal strength metric provided on the InSpectra? StO2 Tissue Oxygenation Monitor, Model 650. There is growing interest regarding the physiologic meaning of THI and whether a clinically useful correlation between THI and blood hemoglobin concen- tration exists. A series of in vitro and in vivo experiments was performed to evaluate whether THI has potential utility beyond its primary purpose of helping InSpectra? device users optimally position a StO2 sensor over muscle tissue. Methods: The THI and tissue hemoglobin oxygen satu