Thrombospondin-1 as a Paradigm for the Development of Antiangiogenic Agents Endowed with Multiple Mechanisms of Action 英文参考文献.docVIP
- 1、本文档共38页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Thrombospondin-1 as a Paradigm for the Development of Antiangiogenic Agents Endowed with Multiple Mechanisms of Action 英文参考文献
Pharmaceuticals 2010, 3, 1241-1278; doi:10.3390/ph3041241
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
Thrombospondin-1 as a Paradigm for the Development of
Antiangiogenic Agents Endowed with Multiple Mechanisms
of Action
Marco Rusnati 1,*, Chiara Urbinati 1, Silvia Bonifacio 2, Marco Presta 1 and Giulia Taraboletti 2
1
Unit of General Pathology and Immunology, Department of Biomedical Sciences and
Biotechnology, School of Medicine, University of Brescia, Brescia, 25123, Italy;
E-Mails: urbinati@med.unibs.it (C.U.); presta@med.unibs.it (M.P.)
2
Tumor Angiogenesis Unit, Department of Oncology, Mario Negri Institute for Pharmacological
Research, Bergamo, Italy; E-Mails: bonifacio@marionegri.it (S.B.); taraboletti@marionegri.it (G.T.)
* Author to whom correspondence should be addressed. E-Mail: rusnati@med.unibs.it;
Tel.: +39-030-3717315; Fax: +39-030-3701157.
Received: 14 February 2010; in revised form: 20 April 2010 / Accepted: 22 April 2010 /
Published: 23 April 2010
Abstract: Uncontrolled neovascularization occurs in several angiogenesis-dependent
diseases, including cancer. Neovascularization is tightly controlled by the balance between
angiogenic growth factors and antiangiogenic agents. The various natural angiogenesis
inhibitors identified so far affect neovascularization by different mechanisms of action.
Thrombospondin-1 (TSP-1) is a matricellular modular glycoprotein that acts as a powerful
endogenous inhibitor of angiogenesis. It acts both indirectly, by sequestering angiogenic
growth factors and effectors in the extracellular environment, and directly, by inducing an
antiangiogenic program in endothelial cells following engagement of specific receptors
including CD36, CD47, integrins and proteoglycans (all involved in angiogenesis ). In
view of its central, multifaceted role in angiogenesis, TSP-1 has served as a source of
antiangiogenic tools, including TSP-
您可能关注的文档
- Thermus thermophilus Strains Active in Purine Nucleoside Synthesis 英文参考文献.doc
- Thin films of In2O3SiO for Humidity Sensing Applications 英文参考文献.doc
- Thin Film on CMOS Active Pixel Sensor for Space Applications 英文参考文献.doc
- Thiadiazines, N,N-Heterocycles of Biological Relevance 英文参考文献.doc
- Thermographic Phosphors for High Temperature Measurements Principles, Current State of the Art and Recent Applications 英文参考文献.doc
- Thermal Actuation Based 3-DoF Non-Resonant Microgyroscope Using MetalMUMPs 英文参考文献.doc
- Think (Gram) negative! 英文参考文献.doc
- Thinking outside the curve, part II modeling fetal-infant mortality 英文参考文献.doc
- Thinking outside the curve, part I modeling birthweight distribution 英文参考文献.doc
- Thioacetyl-Terminated Ferrocene-Anthraquinone Conjugates Synthesis, Photo- and Electrochemical Properties Triggered by Protonation-Induced Intramolecular Electron Transfer 英文参考文献.doc
- 探寻科学与公平:重庆市体育高考评分标准深度剖析.docx
- 剖析《新思路大学英语》语料:文化输入的深度洞察与策略探寻.docx
- 高电荷态离子在玻璃毛细管中的导向与聚焦效应:机制、影响因素及应用探索.docx
- 化痰醒神开窍针法预防卒中相关性肺炎的疗效与机制探究.docx
- 华蟾素在结直肠癌术后化疗中的增效减毒作用:一项前瞻性研究.docx
- 韩国普通高中新课程改革:历程、内容与启示.docx
- 室内多光源照明下可见光定位技术:原理、挑战与突破.docx
- 数据驱动视角下调节阀故障诊断方法的深度剖析与实践.docx
- 血清25羟维生素D3水平对2型糖尿病大血管病变的影响机制及临床关联探究.docx
- 有氧与力量训练对原发性高血压患者血压及脂代谢影响的多维度探究.docx
最近下载
- 国家安全论文2000字范文(精选5篇).docx VIP
- 用电检查员技能培训课件—三相四线计量装置错接线分析及操作.pptx
- 第24课 人民解放战争(课件)-【中职专用】《中国历史》.pptx
- 讲好红色故事传承红色精神红色革命故事学习PPT.pptx VIP
- 心理健康指导师考试题库及答案.doc VIP
- 电子基础培训介绍.pptx VIP
- 离心式压缩机培训PPT.pptx VIP
- 犯罪心理学大学校园故意杀人罪的分析以云南大学学生马加爵杀人案为例.pdf
- SLT 631.1-2025 水利水电工程单元工程施工质量验收标准 第1部分:土石方工程.docx
- 高考历史判断题练习及答案.docx VIP
文档评论(0)