Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity 英文参考文献.docVIP

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Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity 英文参考文献.doc

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Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity 英文参考文献

Open Access Re rch 2007CuietVoal.lumesea8, Issue 6, Article R122 Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity Yuxia Cui*, Sandra J McBride*, Windy A Boyd?, Scott Alper?§ and Jonathan H Freedman*? Addresses: *Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC 27708, USA. ?Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. ?Laboratory of Environmental Lung Disease, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA. §Department of Medicine, Duke University Medical Center, Durham, NC 27707, USA. Correspondence: Jonathan H Freedman. Email: freedma1@ Published: 25 June 2007 Received: 9 March 2007 Revised: 22 May 2007 Accepted: 25 June 2007 Genome Biology 2007, 8:R122 (doi:10.1186/gb-2007-8-6-r122) The electronic version of this article is the complete one and can be found online at /2007/8/6/R122 ? 2007 Cui et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ProfilinginpvoGlvleodbaithenl acneresponselalluylsairstorfatftohfieccadmiumktranscriptionaling, metabolic presponserocessestoancadmiumd proteolyexposuresis, and foinr itCaenorhabditisthe signaling proteinelegansKEL-8./itreveals/p roles for genes Abstract Background: Exposure to cadmium is associated with a variety of human diseases. At low concentrations, cadmium activates the transcription of stress-responsive genes, which can prevent or repair the adverse effects caused by this metal. Results: Using Caenorhabditis elegans, 290 genes were identified that are differentially expressed (1.5-fold) following a 4 or 24 hour exposure