Tumor necrosis factor α-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis 英文参考文献.docVIP

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Tumor necrosis factor α-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis 英文参考文献.doc

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Tumor necrosis factor α-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis 英文参考文献

Available online /content/11/4/R118 Research article Open Access Vol 11 No 4 Tumor necrosis factor α-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis Asuka Inoue1, Isao Matsumoto1,2, Yoko Tanaka1, Keiichi Iwanami1, Akihiro Kanamori3, Naoyuki Ochiai3, Daisuke Goto1, Satoshi Ito1 and Takayuki Sumida1 1Division of Clinical Immunology, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan 2PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan 3Department of Orthopedic Surgery, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan Corresponding author: Isao Matsumoto, ismatsu@md.tsukuba.ac.jp Received: 6 Feb 2009 Revisions requested: 11 Mar 2009 Revisions received: 1 Aug 2009 Accepted: 6 Aug 2009 Published: 6 Aug 2009 Arthritis Research Therapy 2009, 11:R118 (doi:10.1186/ar2779) This article is online at: /content/11/4/R118 ? 2009 Inoue et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Tumor necrosis factor-alpha (TNFα) plays a pivotal Results Among the arrayed TNFα-related genes, the expression of TIARP mRNA was the highest (more than 20 times the control). TIARP mRNA was detected specifically in joints and spleens of arthritic mice, and their levels in the synovia correlated with severity of joint swelling. Treatment with anti- TNF mAb significantly reduced TIARP mRNA expression in splenocytes. Among the splenocytes, CD11b+ cells were the main source of TIARP mRNA. Immunohistochemistry showed that