Trends in genomic evo-devo 英文参考文献.docVIP

/2002/3/7/reports/4019.1 Meeting report Trends in genomic ‘evo-devo’ Chun-che Chang* and Charles E Cook? Addresses: *Department of Genetics, University of Leicester, University Road, Leicester LE1 7HR, UK. ?University Museum of Zoology, Downing Street, Cambridge CB2 3EJ, UK. Correspondence: Charles E Cook. E-mail: ccook@ Published: 27 June 2002 GenomeBiology 2002, 3(7):reports4019.1–4019.2 The electronic version of this article is the complete one and can be found online at /2002/3/7/reports/4019 ? BioMed Central Ltd (Print ISSN 1465-6906; Online ISSN 1465-6914) some gene families have expanded massively in one taxon A report on the joint Spring meeting of the British Society of when compared to the other. Bor example, in C. elegans Developmental Biology and the Genetics Society, York, UK, there are 270 genes encoding nuclear hormone receptors, 20-23 March 2002. but in Drosophila there are only 21. By contrast, there are only 7 trypsin-like peptidases in the worm but 200 in the fly. In both species most gene knockouts lack a phenotype, Evolutionary biologists look at an organism and want to understand its history: how it evolved, where it came from, and who its closest relatives are. Developmental biologists want to understand how a single fertilized egg grows into an adult organism. In the 1980s new molecular techniques allowed developmental geneticists to manipulate develop- ment, at least in a few model organisms, in order to explore the molecular and genetic bases of developmental processes. At the same time the discovery that the Hox transcription factors are fundamentally important during development and occur in most or all animals demonstrated that many aspects of development are shared across taxa. The two fields overlapped when biologists began to manipulate dif- ferent species and compare the results of those manipula- which means that it