Transport lattice models of heat transport in skin with spatially heterogeneous, temperature-dependent perfusion 英文参考文献.docVIP

BioMedical Engineering OnLine BioMedCentral Research Open Access Transport lattice models of heat transport in skin with spatially heterogeneous, temperature-dependent perfusion TR Gowrishankar1, Donald A Stewart1, Gregory T Martin1,2 and James C Weaver*1 Address: 1Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and 2Thermal Technologies, Inc., Cambridge, MA 02139, USA Email: TR Gowrishankar - tgowrish@; Donald A Stewart - stewy@; Gregory T Martin - gmartin@; James C Weaver* - jcw@ * Corresponding author Published: 17 November 2004 Received: 23 April 2004 Accepted: 17 November 2004 BioMedical Engineering OnLine 2004, 3:42 doi:10.1186/1475-925X-3-42 This article is available from: /content/3/1/42 ? 2004 Gowrishankar et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Investigation of bioheat transfer problems requires the evaluation of temporal and spatial distributions of temperature. This class of problems has been traditionally addressed using the Pennes bioheat equation. Transport of heat by conduction, and by temperature-dependent, spatially heterogeneous blood perfusion is modeled here using a transport lattice approach. Methods: We represent heat transport processes by using a lattice that represents the Pennes bioheat equation in perfused tissues, and diffusion in nonperfused regions. The three layer skin model has a nonperfused viable epidermis, and deeper regions of dermis and subcutaneous tissue with perfusion that is constant or temperature-dependent. Two cases are considered: (1) surface contact heating and (2) spatially distributed heating. The model is