Transfer of immunoglobulins through the mammary endothelium and epithelium and in the local lymph node of cows during the initial response after intramammary challenge with E. coli endotoxin 英文参考文献.docVIP

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Transfer of immunoglobulins through the mammary endothelium and epithelium and in the local lymph node of cows during the initial response after intramammary challenge with E. coli endotoxin 英文参考文献.doc

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Transfer of immunoglobulins through the mammary endothelium and epithelium and in the local lymph node of cows during the initial response after intramammary challenge with E. coli endotoxin 英文参考文献

Acta Veterinaria Scandinavica BioMedCentral Research Open Access Transfer of immunoglobulins through the mammary endothelium and epithelium and in the local lymph node of cows during the initial response after intramammary challenge with E. coli endotoxin Karin ?stensson*1 and Shichun Lun2 Address: 1Department of Clinical Sciences, Division of Reproduction, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden and 2Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA Email: Karin ?stensson* - karin.ostensson@kv.slu.se; Shichun Lun - slun1@ * Corresponding author Published: 2 July 2008 Received: 3 April 2008 Accepted: 2 July 2008 Acta Veterinaria Scandinavica 2008, 50:26 doi:10.1186/1751-0147-50-26 This article is available from: /content/50/1/26 ? 2008 ?stensson and Lun; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The first hours after antigen stimulation, interactions occur influencing the outcome of the immunological reaction. Immunoglobulins originate in blood and/or are locally synthesized. The transfer of Ig isotypes (Igs) in the udder has been studied previously but without the possibility to distinguish between the endothelium and the epithelium. The purpose of this study was to map the Ig transfer through each barrier, separately, and Ig transfer in the local lymph nodes of the bovine udder during the initial innate immune response. Methods: The content of IgG1, IgG2, IgM, IgA and albumin (BSA) was examined in peripheral/afferent mammary lymph and lymph leaving the supramammary lymph nodes, and in blood and milk before (0 h) and during 4 hours after intramammary challenge w