Trends in antibacterial resistance among Streptococcus pneumoniae isolated in the USA update from PROTEKT US Years 1–4 英文参考文献.docVIP
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Trends in antibacterial resistance among Streptococcus pneumoniae isolated in the USA update from PROTEKT US Years 1–4 英文参考文献
Annals of Clinical Microbiology and
Antimicrobials
BioMedCentral
Research
Open Access
Trends in antibacterial resistance among Streptococcus pneumoniae
isolated in the USA: update from PROTEKT US Years 1–4
Stephen G Jenkins*1, Steven D Brown?2 and David J Farrell?3
Address: 1Mount Sinai Medical Center, Mount Sinai School of Medicine, New York, NY, USA, 2Clinical Microbiology Institute, Wilsonville, OR,
USA and 3G.R. Micro Ltd, 7-9 William Road, London, UK
Email: Stephen G Jenkins* - stephen.jenkins@; Steven D Brown - sbrown@;
David J Farrell - d.farrell@grmicro.co.uk
* Corresponding author ?Equal contributors
Published: 11 January 2008
Received: 9 February 2007
Accepted: 11 January 2008
Annals of Clinical Microbiology and Antimicrobials 2008, 7:1
doi:10.1186/1476-0711-7-1
This article is available from: /content/7/1/1
? 2008 Jenkins et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The increasing prevalence of resistance to established antibiotics among key bacterial
respiratory tract pathogens, such as Streptococcus pneumoniae, is a major healthcare problem in the USA.
The PROTEKT US study is a longitudinal surveillance study designed to monitor the susceptibility of key
respiratory tract pathogens in the USA to a range of commonly used antimicrobials. Here, we assess the
geographic and temporal trends in antibacterial resistance of S. pneumoniae isolates from patients with
community-acquired respiratory tract infections collected between Year 1 (2000–2001) and Year 4
(2003–2004) of PROTEKT US.
Methods: Antibacterial minimum inhibitory concentrations were determined centrally using the Clinical
and Laboratory Standards Institute (CLSI) broth microdil
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