Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998–2004 英文参考文献.docVIP

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Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998–2004 英文参考文献.doc

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Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998–2004 英文参考文献

BMC Pediatrics BioMedCentral Research article Open Access Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998–2004 Andrew S Coco*, Michael A Horst and Angela S Gambler Address: Research Institute Department of Family Medicine, Lancaster General Hospital, North Duke Street, Lancaster, PA 17604-3555, USA Email: Andrew S Coco* - ascoco@; Michael A Horst - mahorst@; Angela S Gambler - sanders@ * Corresponding author Published: 24 June 2009 Received: 27 February 2009 Accepted: 24 June 2009 BMC Pediatrics 2009, 9:41 doi:10.1186/1471-2431-9-41 This article is available from: /1471-2431/9/41 ? 2009 Coco et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Overuse of broad-spectrum antibiotics is associated with antibiotic resistance. Acute otitis media (AOM) is responsible for a large proportion of antibiotics prescribed for US children. Rates of broad-spectrum antibiotic prescribing for AOM are unknown. Methods: Analysis of the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey, 1998 to 2004 (N = 6,878). Setting is office-based physicians, hospital outpatient departments, and emergency departments. Patients are children aged 12 years and younger prescribed antibiotics for acute otitis media. Main outcome measure is percentage of broad-spectrum antibiotics, defined as amoxicillin/clavulanate, macrolides, cephalosporins and quinolones. Results: Broad-spectrum prescribing for acute otitis media increased from 34% of visits in 1998 to 45% of visits in 2004 (P .001 for trend). The trend was primarily attributable to an increase in prescribing of amoxicillin/c