Trends in reported AIDS defining illnesses (ADIs) among participants in a universal antiretroviral therapy program an observational study 英文参考文献.docVIP

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Trends in reported AIDS defining illnesses (ADIs) among participants in a universal antiretroviral therapy program an observational study 英文参考文献.doc

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Trends in reported AIDS defining illnesses (ADIs) among participants in a universal antiretroviral therapy program an observational study 英文参考文献

Jafarietal.AIDSResearchandTherapy2011,8:31 /content/8/1/31 RESEARCH OpenAccess TrendsinreportedAIDSdefiningillnesses(ADIs) amongparticipantsinauniversalantiretroviral therapyprogram:anobservationalstudy SiavashJafari1,2,KeithChan2,KewanAboulhosn3,BenitaYip2,VivianeDLima2,4,RobertSHogg2,5, JulioMontaner2,4 andDavidMMoore2,4* Abstract Background:WeexaminedtrendsinAIDS-definingillnesses(ADIs)amongindividualsreceivinghighlyactive antiretroviraltherapy(HAART)inBritishColumbia(BC),CanadatodeterminewhetherdeclinesinADIscouldbe contributingtopreviouslyobservedimprovementsinlife-expectancyamongHAARTpatientsinBCsince1996. Methods:HAART-na?veindividualsaged≥18yearswhoinitiatedtreatmentinBCeachofthefollowingtime- periods1996-1998;1999-2001;2002-2004;2005-2007wereincluded.Theproportionofparticipantswith reportedADIswereexaminedforeachtimeperiodandtrendswereanalyzedusingtheCochran-ArmitageTrend Test.CoxproportionalhazardsmodelswereusedtoexaminefactorsassociatedwithADIs. Results:Atotalof3721individuals(81%male)initiatedHAARTduringthestudyperiod.Atotalof251reportsof ADIswerereceivedfrom214uniquepatients.Theseoccurredinamedianof4months(IQR=1-19months)from HAARTinitiation.TheproportionofindividualswithareportedADIdidnotchangesignificantlyfrom4.6%inthe earliesttimeperiodto5.8%inthelatestperiod(p=0.181fortestoftrend).Therewerenosignificantdeclinesin anyspecificADIoverthestudyperiod.MultivariableCoxmodelsfoundthatindividualsinitiatingHAARTduring 2002-04wereatanincreasedriskofADIs(AHR=1.55;95%CI1.04-2.32)incomparisonto1996-98,butthere werenosignificantdifferencesinothertimeperiods. Conclusions:TrendsinreportedADIsamongindividualsreceivingHAARTsince1996inBCdonotappearto parallelimprovementsinlife-expectancyoverthesameperiod. Background Life-expectancy of individuals initiating HAART in Theintroduction ofhighly active antiretroviral therapy British Columbia (BC), Canada has continued to (HAART) in 1996 resulted in significant reductions in increasesincetheintroductionofHAART[1].In199