Ultrasound Promoted Synthesis of Bis(substituted pyrazol-4-ylcarbonyl)-Substituted Thioureas 英文参考文献.docVIP

Molecules 2009, 14, 1423-1428; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication Ultrasound Promoted Synthesis of Bis(substituted pyrazol-4- ylcarbonyl)-Substituted Thioureas Li Xiao, Chen-Jiang Liu * and Yan-Ping Li School of Chemistry and Chemical Engineering, Xinjiang University, Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education, 830046 Urumqi, P. R. China; E-mails: xiaol163.com (L.X.), lyp_666@163.com (Y-P.L.) * Author to whom correspondence should be addressed. E-mail: pxylcj@126.com (C-J.L); Tel.: +86-9918581211; Fax: +86-9918582809. Received: 28 February 2009; in revised form: 15 March 2009 / Accepted: 23 March 2009 / Published: 31 March 2009 Abstract: A series of novel bis(substituted pyrazol-4-ylcarbonyl)-substituted thioureas have been synthesized by the reactions of substituted pyrazol-4-ylcarbonyl isothiocyanates with different diamines under ultrasound irradiation and classical heating method at 20-25 °C. In general, substantial improvement in rates and modest yields increases were observed when reactions were carried out under sonication, compared with the classical heating method. The structures of these compounds have been elucidated by elemental and spectral (IR, 1H-NMR) analysis. Keywords: Thiourea; Pyrazole; Diamine; Ultrasound; Synthesis. Introduction Heterocycles bearing a pyrazole moiety represent an interesting class of compounds possessing a wide spectrum of biological and pharmacological activities, such as herbicidal [1], antitumor [2], antibacterial [3], antileukemic [4], anti-inflammatory [5] properties. On the other hand, thiourea compounds have received much attention because of their wide range of biological properties such as antituberculosis [6], anticancer [7], anti-HIV [8], antimicrobial [9] activity. The use of ultrasound in chemistry, usually known as sonochemistry, has grown spectacularly in