Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation 英文参考文献.docVIP

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Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation 英文参考文献.doc

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Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation 英文参考文献

Molecules 2012, 17, 14146-14158; doi:10.3390/molecules171214146 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation Chengyuan Liang, Hailong Jiang, Zhiguang Zhou, Dong Lei, Yu Xue and Qizheng Yao * School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China; E-Mails: chengyuanliang@ (C.L.); jianghailongsj@163.com (H.J.); zhouzhiguang0728@126.com (Z.Z.); leidong0066@126.com (D.L.); xueyu0816@126.com (Y.X.) * Author to whom correspondence should be addressed; E-Mail: qz_yao@; Tel./Fax: +86-25-8663-4730. Received: 23 October 2012; in revised form: 12 November 2012 / Accepted: 23 November 2012 / Published: 28 November 2012 Abstract: An efficient and convenient approach for one-pot synthesis of 3-substituted chroman-2,4-diones via a three-component reaction of aromatic aldehydes, 4-hydroxy- coumarins and diverse pyrazolone derivatives was described. The combinatorial synthesis for this methodology was achieved by applying ultrasound irradiation in the absence of activator while making use of water as green solvent. Additionally, novel chroman-2,4-dione derivatives attached to an edaravone moiety represent an exploitable source of brand new anticancer agents. In comparison with conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and atom efficiency are prominent features of this sonocatalyzed procedure. Keywords: chroman-2,4-diones; multicomponent reactions (MCRs); ultrasonic irradiation; green chemistry; coumarin; edaravone 1. Introduction In recent years, ultrasound-assisted organic synthesis (UAOS) utilizing environmentally benign reagents and conditions has been one of the most fascinating developments in the arena of modern synthetic chemistry owing to its green credentials [1–5]. T