Uncoated and coated blood contact surfaces of a hollow-fiber oxygenator an in-vitro comparison 英文参考文献.docVIP

Abstracts International Symposium on the Pathophysiology of CPB P1 Abstracts of the International Symposium on the Pathophysiology of Cardiopulmonary Bypass Aachen, December 12 1998 1 Effects of blood viscosity on renal function during cardiopulmonary bypass — investigations in infants and experimental setting in pig kidneys S Dittrich Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany, and Humboldt University, Berlin 1 , M Priesemann 1 , A Schuth 1 , C Müller 2 , T Fischer 1 , V Alexi-Meskishvili and PE Lang 1 1 1 2 Departement of Clinical Chemistry and Biochemistry, Charité, Objectives: Acute renal failure (ARF) is a common complication following open heart surgery especially in infants. Effects of blood viscosity on renal function are well known, but have not been investigated in cardiopulmonary bypass (CPS) as yet. indicating moderate glomerular and tubular damage. During AT, blood was hemodiluted to a hemoglobin of 8.4 ±0.4 g/dl. Thus, blood viscosity during AT and hypothermia was slightly below pre-CPB values. Lower blood viscosity was related to less renal damage (P 0.01). Material and methods: We investigated blood viscosity and differ- ent markers of glomerular and tubular renal function in a group of 37 infants below 18 month of age, receiving CPS surgery for dif- ferent diagnoses. In isolated pig-kidneys, group I (n = 14) was perfused with a hemoglobin of 10.2 ±0.3 g/dl and group II (n = 14) was hemodi- luted to 6.5 ±0.9 g/dl. Group II kidneys showed lower vascular resistance, elevated creatinine clearance, elevated oxygen con- sumption and elevated sodium reabsorption (P 0.05). In an experimental setting, we investigated 28 isolated pig-kidneys with different hematocrits in an autologous blood perfused model. Conclusions: Reducing blood viscosity below physiological values improves tubular as well as glomerular function unde