Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1-pyrazolo[1,2-b]phthalazine] Derivatives 英文参考文献.docVIP

Molecules 2012, 17, 8674-8686; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1-pyrazolo[1,2-b]phthalazine] Derivatives Juxian Wang 1, Xiaoguang Bai 1, Changliang Xu 1, Yucheng Wang 1,*, Wei Lin 2, Yi Zou 2 and Daqing Shi 2,* 1 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union, Medical College, Beijing 100050, China 2 Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China * Authors to whom correspondence should be addressed; E-Mails: wyc9999@126.com (Y.W.); dqshi@263.net (D.S.); Tel./Fax: +86-10-6316-5263 (Y.W.). Received: 8 June 2012; in revised form: 28 June 2012 / Accepted: 13 July 2012 / Published: 23 July 2012 Abstract: A series of 3-aminospiro[indoline-3,1-pyrazolo[1,2-b]phthalazine]-2,5,10-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and phthalhydrazide catalyzed by piperidine under ultrasound irradiation. For comparison the reactions were carried out under both conventional and ultrasonic conditions. In general, improvement in rates and yields were observed when the reactions were carried out under sonication compared with classical conditions. Keywords: multicomponent; ultrasound; spiro[indoline-3,1-pyrazolo[1,2-b]phthalazine]; spirooxindole 1. Introduction The challenge of achieving the ideal synthesis has been pursued aggressively since scientists began to construct molecules. Of course, there are many other factors that affect the aspects of synthesis, such as cost, starting material availability, safety, environmental concerns, and overall ease of the process, including work up and purification [1]. Traditional s