Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus 英文参考文献.docVIP

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Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus 英文参考文献.doc

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Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus 英文参考文献

Leeetal.ArthritisResearchTherapy2011,13:R63 /content/13/2/R63 RESEARCH ARTICLE OpenAccess Underexpressionofmitochondrial-DNAencoded ATPsynthesis-relatedgenesandDNArepair genesinsystemiclupuserythematosus Hooi-MingLee1,HidehikoSugino1,ChiekoAoki2andNorihiroNishimoto1,2* Abstract Introduction:Systemiclupuserythematosus(SLE)isaprototypicalautoimmunediseasecharacterizedbyvarious systemicsymptomsandmultipleorgandamage.WeclarifybiologicalandfunctionalabnormalitiesinSLEby comparingthegeneexpressionprofilesofSLEpatientswiththoseofhealthyindividuals. Methods:Geneexpressionprofilesfromtheperipheralbloodof21SLEpatientsand45healthyindividualswere obtainedusingaDNAmicroarray.Geneontologyanalysisandnetworkpathwayanalysiswereperformedonthe genesdifferentiallyexpressedbetweenSLEandhealthyindividuals. Results:Atotalof2,329upregulatedgenesand1,884downregulatedgenesweredifferentiallyexpressed.Gene ontologyanalysisrevealedthattheupregulatedgeneswereclassifiedasresponsetobioticstimulusgenes,which mainlyincludesgenesrelatedtoimmuneresponse.Abnormalitiesinothercategoriessuchascellmotilityand regulationofapoptosiswerealsorevealed.Downregulatedgenesweremainlysortedintotwogenecategories, sensoryperceptionandresponsetoradiation/light.ThesensoryperceptiongenesincludedATPase/ATPase domain-containinggenes,myosin-relatedgenes,andtwoexcisionrepaircross-complementinggenes,whichare involvedinDNArepair.Othergenesinthisgroup-includingthreecrystallingenes,genesencodingthereceptor proteinformelanocyte-stimulatinghormone,andsixmitochondrial-DNAencodedgenes,whichareinvolvedin ATPsynthesis-werealsocategorizedasresponsetoradiationgenes.Usingnetworkpathwayanalysis,IL-6, transforminggrowthfactorbeta1,TNF,andhepatocytenuclearfactor4awerefoundtoplaycentralrolesinthe networksofsensoryperception-relatedmolecules. Conclusions:FunctionalabnormalitiesinATPsynthesisandDNArepairareimplicatedinperipheralbloodcells fromSLEpatients. Introduction abnormalities inapoptosis, impairedclearance ofdying Systemic lupus eryth