Use of the probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients a randomised controlled open pilot study 英文参考文献.docVIP

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Use of the probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients a randomised controlled open pilot study 英文参考文献.doc

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Use of the probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients a randomised controlled open pilot study 英文参考文献

Available online /content/12/6/R136 Research Open Access Vol 12 No 6 Use of the probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients: a randomised controlled open pilot study Bengt Klarin1, G?ran Molin2, Bengt Jeppsson3 and Anders Larsson4 1Department of Anaesthesiology and Intensive Care, University Hospital, SE-221 85 Lund, Sweden 2Applied Nutrition and Food Chemistry, Lund University, Box 117, SE-221 00 Lund, Sweden 3Department of Surgery, University Hospital, SE-205 02 Malm?, Sweden 4Department of Anaesthesiology and Intensive Care, Aalborg Hospital, ?rhus University Hospitals, DK-9000 Aalborg, Denmark Corresponding author: Bengt Klarin, Bengt.Klarin@med.lu.se Received: 25 Jun 2008 Revisions requested: 28 Jul 2008 Revisions received: 27 Aug 2008 Accepted: 6 Nov 2008 Published: 6 Nov 2008 Critical Care 2008, 12:R136 (doi:10.1186/cc7109) This article is online at: /content/12/6/R136 ? 2008 Klarin et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Ventilator-associated pneumonia (VAP) is usually oropharynx and trachea at inclusion and at defined intervals thereafter. caused by aspiration of pathogenic bacteria from the oropharynx. Oral decontamination with antiseptics, such as chlorhexidine (CHX) or antibiotics, has been used as prophylaxis against this complication. We hypothesised that the probiotic bacteria Lactobacillus plantarum 299 (Lp299) would be as efficient as CHX in reducing the pathogenic bacterial load in the oropharynx of tracheally intubated, mechanically ventilated, critically ill patients. Results Potentially pathogenic bacteria that were not present at inclusion were identified in orophary