Vaccination response to tetanus toxoid and 23-valent pneumococcal vaccines following administration of a single dose of abatacept a randomized, open-label, parallel group study in healthy subjects 英文参考文献.docVIP

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Vaccination response to tetanus toxoid and 23-valent pneumococcal vaccines following administration of a single dose of abatacept a randomized, open-label, parallel group study in healthy subjects 英文参考文献.doc

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Vaccination response to tetanus toxoid and 23-valent pneumococcal vaccines following administration of a single dose of abatacept a randomized, open-label, parallel group study in healthy subjects 英文参考文献

Available online /content/9/2/R38 Research article Open Access Vol 9 No 2 Vaccination response to tetanus toxoid and 23-valent pneumococcal vaccines following administration of a single dose of abatacept: a randomized, open-label, parallel group study in healthy subjects Lee Tay1, Francisco Leon2, George Vratsanos3, Ralph Raymond4 and Michael Corbo3 1Clinical Discovery, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA 2Clinical Development, Inflammatory Diseases, MedImmune, 1 MedImmune Way, Gaithersburg, MD 20878, USA 3Global Clinical Research, Immunology, PO Box 4000, Bristol-Myers Squibb, Princeton, NJ 08543-4000, USA 4Global Biometric Sciences, PO Box 4000, Bristol-Myers Squibb, Princeton, NJ 08543-4000, USA Corresponding author: Lee Tay, lee.tay@ Received: 31 Jul 2006 Revisions requested: 31 Aug 2006 Revisions received: 26 Mar 2007 Accepted: 10 Apr 2007 Published: 10 Apr 2007 Arthritis Research Therapy 2007, 9:R38 (doi:10.1186/ar2174) This article is online at: /content/9/2/R38 ? 2007 Tay et al., licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The effect of abatacept, a selective T-cell co-stimulation modulator, on vaccination has not been previously investigated. In this open-label, single-dose, randomized, parallel-group, controlled study, the effect of a single 750 mg infusion of abatacept on the antibody response to the intramuscular tetanus toxoid vaccine (primarily a memory response to a T-cell- dependent peptide antigen) and the intramuscular 23-valent pneumococcal vaccine (a less T-cell-dependent response to a polysaccharide antigen) was measured in 80 normal healthy volunteers. Subjects were uniformly randomized to receive one of four treatme