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A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1
Blasiusetal.GenomeBiology2011,12:R78
/content/12/8/R78
RESEARCH
OpenAccess
Aphospho-proteomicscreenidentifiessubstrates
ofthecheckpointkinaseChk1
MelanieBlasius1?,JosepVForment1?,NehaThakkar1,SebastianAWagner2,ChunaramChoudhary2and
StephenPJackson1*
Abstract
Background:Thecell-cyclecheckpointkinaseChk1isessentialinmammaliancellsduetoitsrolesincontrolling
processessuchasDNAreplication,mitosisandDNA-damageresponses.Despiteitsparamountimportance,how
Chk1controlsthesefunctionsremainsunclear,mainlybecauseveryfewChk1substrateshavehithertobeen
identified.
Results:Here,wecombineachemicalgeneticsappr
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