原创力文档A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis.docVIP
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A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis
Boomeretal.CriticalCare2012,16:R112
/content/16/3/R112
RESEARCH
OpenAccess
Aprospectiveanalysisoflymphocytephenotype
andfunctionoverthecourseofacutesepsis
JonathanSBoomer1?,JenniferShuherk-Shaffer1?,RichardSHotchkiss1,2 andJonathanMGreen1*
Abstract
Introduction:Severesepsisischaracterizedbyaninitialhyper-inflammatoryresponsethatmayprogresstoan
immune-suppressedstateassociatedwithincreasedsusceptibilitytonosocomialinfection.Analysisofsamples
obtainedfrompatientswhodiedofsepsishasidentifiedexpressionofspecificinhibitoryreceptorsexpressedon
lymphocytesthatareassociatedwithcellexhaustion.The
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