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Aberrant glycosylation associated with enzymes as cancer biomarkers
MeanyandChanClinicalProteomics2011,8:7
/content/8/1/7
CLINICAL
PROTEOMICS
REVIEW
OpenAccess
Aberrantglycosylationassociatedwithenzymes
ascancerbiomarkers
DanniLMeany*andDanielWChan
*Correspondence:dmeany1@jhmi.
edu
Abstract
DepartmentofPathology,Johns
HopkinsUniversity,Baltimore,MD
21231,USA
Background:Oneofthenewrolesforenzymesinpersonalizedmedicinebuildson
arationalapproachtocancerbiomarkerdiscoveryusingenzyme-associatedaberrant
glycosylation.Ahallmarkofcancer,aberrantglycosylationisassociatedwith
differentialexpressionsofenzymessuchasglycosyltransferaseandglycosidases.
Theaberrantexpressi
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