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Acetylcholinesterase inhibition ameliorates deficits in motivational drive
Martinowichetal.BehavioralandBrainFunctions2012,8:15
/content/8/1/15
RESEARCH
OpenAccess
Acetylcholinesteraseinhibitionameliorates
deficitsinmotivationaldrive
KeriMartinowich1,3*,KathleenMCardinale1,RobertJSchloesser1,MichaelHsu1,NigelHGreig2and
HusseiniKManji4
Abstract
Background:Apathyisfrequentlyobservedinnumerousneurologicaldisorders,includingAlzheimer’ sand
Parkinson’s,aswellasneuropsychiatricdisordersincludingschizophrenia.Apathyisdefinedasalackofmotivation
characterizedbydiminishedgoal-orientedbehaviorandself-initiatedactivity.Thisstudyevaluatedachronic
restraintstress(CRS)protocolinm
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