Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus.docVIP

Jin et al. Arthritis Research Therapy 2010, 12:R137 /content/12/4/R137 RESEARCH ARTICLE Open Access Abnormalities in circulating plasmacytoid Research article dendritic cells in patients with systemic lupus erythematosus Ou Jin1,2, Sushma Kavikondala1, Mo-Yin Mok1, Lingyun Sun3, Jieruo Gu2, Rong Fu1, Albert Chan1, Joseph Yeung1, Yingjie Nie1 and Chak-Sing Lau*1 Abstract Introduction: Dendritic cells (DCs) are capable of inducing immunity or tolerance. Previous studies have suggested plasmacytoid DCs (pDCs) are pathogenic in systemic lupus erythematosus (SLE). However, the functional