Activated protein C in severe acute pancreatitis without sepsis Not just yet.docVIP

Shankar-Hari and Wyncoll Critical Care 2010,14:188 /content/14/4/188 COMMENTARY Activated protein C in severe acute pancreatitis without sepsis? Not just yet … Manu Shankar-Hari and Duncan Wyncoll* See related research by Pettila et al., /content/14/4/R139/abstract with unregulated activation of the coagulation system. Abstract Evaluation of the coagulation and the endogenous Severe acute pancreatitis (SAP) is characterized by an unregulated systemic proin?ammatory response secondary to activation of trypsin within the pancreatic tissue, resulting in multiple organ fail